Health professionals, cancer clinicians and clinical scientists, scientists working in cancer, representatives of pharmaceutical companies involved in oncology, policy makers, post-doctoral researchers within medicine and science will benefit from participation in the conference.
The conference has been approved by the Royal College of Physicians of Ireland for 12 CPD credits. 1 CPD credit is equivalent to 1 hour of educational activity.
There is one major international airport in Dublin, situated approximately 10km north of the city centre. Dublin is easily accessible from the UK, Continental Europe and the east and west coast of the USA.
Access from Dublin Airport to Dublin City
There are a number of private and public bus services that operate from outside the airport arrivals terminal: Aircoach, a privately run bus service, operates between the airport and a number of city hotels and locations. www.aircoach.ie
Airlink (bus 747), operated by Dublin Bus, will bring you directly from the airport to Busaras, the central bus station, located in the city. www.dublinbus.ie
There are also a number of other public bus services operating between the airport and various destinations
It is also possible to get to Dublin by ferry via Hollyhead, Liverpool and Isle of Man ports in Britain. Dublin has two ferry terminals – Dublin Port, located in the city centre, is serviced by bus and Dun Laoghaire ferry terminal, south of the city, is easily reached by a 20 minute car or DART train journey.
Trinity College Dublin has preferential agreements (applicable to weekdays only, if available) with the following hotels close to the conference venue:
|Trinity City Hotel|
|Phone:||353 (0) 1 6481000|
|Fax:||353 (0) 1 6481010|
|Clayton Hotel Cardiff Lane|
|Phone:||353 (0) 1 6439500|
|Fax:||353 (0) 1 6439510|
|Address:||Sir John Rogerson's Quay,
|O'Callaghan Hotels Dublin|
|Contact:||Maria Lawlor/Jeremy O’Keeffe|
|Phone:||353 (0) 1 6073900|
|Fax:||353 (0) 1 6615663|
O'Callaghan Hotels has three
Mont Clare Hotel
Conference dinner is not included in the conference registration fee and needs to be booked separately.
The dress code for the dinner is business attire.
|9.00-9.20||WELCOME ADDRESS AND CONFERENCE OPENING|
|SESSION 1:||Molecular classification of tumours: its importance in the cancer care pathway of patients|
|Chairs: Maeve Lowery, Stephen Finn|
|Janessa Laskin Medical Oncologist, BC Cancer Agency|
|Daniel Renouf Medical Oncologist, BC Cancer Agency|
|David Gallagher Medical Oncologist, TSJCI|
|11.10-11.35||Coffee Break and Poster Viewing|
|SESSION 2:||Cancer Risk Factors and Prevention|
|Chairs: John O'Leary, Barry O'Connell|
|11.35||Dopamine Signaling in Lung Cancer: Implications for Cancer Prevention and Therapy|
|Brid Ryan, NCI|
|Prof. Richard Sullivan, Kings Health Partners Institute of Cancer Policy and Global Health|
|12.35||Colorectal cancer: prevention requires shared responsibility|
|Amanda Cross - Imperial College London|
|13.35-14.20||Lunch and Poster Viewing|
|SESSION 3:||Tumour Microenvironment|
|Chairs: Jacintha O’Sullivan, Elisabeth Vandenberghe|
|14.20||Breast cancer and new aspects of glutamine metabolism: metformin, exosomes, hormone resistance|
|Prof. Adrian Harris. CRUK Prof of Medical Oncology, University of Oxford|
|Prof. Johanna Joyce. Ludwig Institute for Cancer Research, Lausanne|
|15.20||Targeting tumour-stroma cells to improve therapies in B cell malignancies|
|Dr. Ingo Ringhausen, Cambridge|
|16.20-16.40||Coffee Break and Poster Viewing|
|16.40||Introduction to Burkitt awardee|
|19.00||Conference dinner/presentation of 2019 Burkitt Medal|
|SESSION 4:||Advances in Immunotherapy|
|Chairs: Michael McCarthy, Cliona O’Farrelly|
|Dr. Seth Coffelt, Beatson Institute, Glasgow|
|09.30||Autophagy modulation as an example of precision cancer (immuno)therapy|
|Assistant Professor Lorenzo Galluzzi, Cornell|
|Neil Segal, Medical Onc MSKCC|
|11.00-11.30||Coffee Break and Poster Viewing|
|SESSION 5:||Molecular agents in Radiation Oncology; Future Directions|
|Chairs: Lorraine O’Driscoll, Frances Duane|
|11.30||Development and pre-clinical validation of dual-function radiation modulating nanoparticles – successes and challenges|
|Dr. Jonathan Coulter, QUB|
|Dr. Conchita Vens, Netherlands Cancer Institute|
|12.00||Novel and Drug and Radiotherapy Combinations – Back to the Future?|
|Professor Gerry Hanna, Peter MacCallum Cancer Centre|
|13.10-14.30||Lunch and poster viewing/judging|
|SESSION 6:||Academic Cancer Centres|
|Panel: John Kennedy, Lorcan Birthistle, Linda Doyle, Susan O’Reilly|
|Prof. Rene Medema, Director of Research, Netherlands Cancer Institute|
|Dr. Jerome Coffey, Director of National Cancer Control Programme|
|Paul Browne, Director of Trinity St. James’s Cancer Institute|
|16.30||Concluding session followed by awards ceremony|
Adrian L Harris is the Cancer Research UK Professor of Medical Oncology at the University of Oxford and directs the Cancer Research UK Molecular Oncology Laboratories at the Weatherall Institute of Molecular Medicine (WIMM). He is a Consultant Medical Oncologist and a Professorial Fellow of St Hugh’s College Oxford. He is Editor-in-Chief of the British Journal of Cancer and on the Editorial Board of Cancer Cell. He is a Senior Investigator in the National Institute of Health Research and a Fellow of the Academy of Medical Sciences.
He is a ‘Highly Cited Researcher 2014’ ranking among the top 1% most cited for their subject field and year of publication—between 2002 and 2012 and included in Thompson Reuters ‘2014 World’s most Influential Scientific Minds.’ He is also listed in Boyack KW, et al. A list of highly influential biomedical researchers, 1996-2011. Eur J Clin Invest. 2013 43:1339-65. These are Top 400 world-wide cited investigators in all biomedical fields. He has published over 500 papers and there are over 145,000 citations to them, h-index 184.
He has received a Platinum Merit Award from then National Health Service for the last 15 years, given to the 200 most outstanding consultants for all specialities.
He trained in Medicine and Biochemistry at Liverpool University, did a DPhil at Oxford University then trained at the Royal Marsden Hospital in Medical Oncology. He was appointed Professor of Clinical Oncology at Newcastle-upon-Tyne in 1982. Since 1988 he has been the Professor of Medical Oncology at Oxford University. He directs the Molecular Oncology Laboratories at the Weatherall Institute of Molecular Medicine. He has managed breast cancer patients for over 30 years.
His major laboratory interests involve the role of hypoxia in breast tumour biology, and tumour angiogenesis, the metabolic response to hypoxia, microRNAs induced by hypoxia and hypoxia-induced cell death. He has conducted many predictive and prognostic studies and early exploratory phase trials in new drug development, molecular pathology and biomarkers, to translate laboratory findings to clinical relevance and development of new agents.
In the Department of Oncology over 20 Phase I and II trials are run and current trials include new drugs blocking angiogenesis, metabolism inhibitors, DNA repair, immunotherapy, inhibitors of signal transduction and their interactions with radiotherapy. Specific emphasis is on classification of tumours by functional imaging, molecular profiles, and pharmacodynamic endpoints to targeted therapies.
Lorenzo Galluzzi (born 1980) is currently Assistant Professor of Cell Biology in Radiation Oncology with the Department of Radiation Oncology of the Weill Cornell Medical College (New York, NY, USA), Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine (New Haven, CT, USA), Honorary Associate Professor with the Faculty of Medicine of the Paris Descartes University (Paris, France), and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara (Ferrara, Italy) and the Graduate School of Pharmacological Sciences of the University of Padova (Padova, Italy).
Prior to joining Weill Cornell Medical College (2017), Lorenzo Galluzzi was a Junior Scientist of the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2012-2016). Lorenzo Galluzzi did his post-doctoral training at the Gustave Roussy Cancer Center (Villejuif, France; 2009-2011), after receiving his PhD from the Paris Sud University (Le Kremlin-Bicetre, France; 2005-2008). He is also Associate Director of the European Academy for Tumor Immunology (EATI), Co-chair of the Society for Immunotherapy of Cancer (SITC) Immunogenic Cell Death Working Group, and Founding Member of the European Research Institute for Integrated Cellular Pathology (ERI-ICP).
Lorenzo Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. In particular, he provided profound insights into the links between adaptive stress responses in cancer cells and the activation of a clinically relevant tumor-targeting immune response in the context of chemotherapy and radiation therapy. Lorenzo Galluzzi has published more than 400 scientific articles in international peer-reviewed journals. According to a survey published by Lab Times, he is currently the 6th and the youngest of the 30 most-cited European cell biologists (relative to the period 2007–2013), and he was nominated Highly Cited Researcher by Clarivate Analytics (formerly, Thomson Reuter) in 2016 and 2018. Lorenzo Galluzzi currently operates as Editor-in-Chief of three journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, and Molecular and Cellular Oncology (which he co-founded in 2013). In addition, Lorenzo Galluzzi currently serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease.
Associate Professor Gerry Hanna is the Director of Radiation Oncology at the Peter MacCallum Cancer Centre, Melbourne and holds an honorary appointment with the University of Melbourne. A/Prof Hanna’s research interests are the use of PET/CT in radiotherapy planning for lung cancer, mechanisms of radiotherapy resistance, technical radiotherapy, stereotactic ablative radiotherapy and systemic therapy and immunotherapy combinations with radiotherapy. He is chief investigator of the International Atomic Energy Agency’s “PERTAIN” study and previous co-chief Investigator of the CONCORDE study, a UK study of novel agents in combination with radiotherapy in the treatment of lung cancer. He is the Thoracic Sub-Study lead for the SARON study and a TMG member for the UK’s HALT and CONFIRM studies.
Ingo Ringshausen studied medicine at the Johannes Gutenberg University in Mainz/ Germany and London/ Canada. After his graduation in 1999 he started his medical training in Internal Medicine and Haematology/ Oncology at the Technical University in Munich. Between 2003 and 2006 he joined the group of Gerard Evan at UCSF on a postdoctoral fellowship. After his board certification in 2010 he became a Consultant in the Department of Haematology/ Oncology in Munich and subsequently an independent group leader. In 2014 he joined the Department of Haematology in Cambridge and is now appointed as Consultant Haematologist at Addenbrooke’s hospital and a Principal Investigator at the Cambridge Stem Cell Institute.
Seth Coffelt is a Senior Research Fellow within the Institute of Cancer Sciences at the University of Glasgow. His lab is based at the Cancer Research UK Beatson Institute. Seth obtained his Ph.D. from Tulane University in New Orleans, Louisiana, USA, in 2006. He undertook his first postdoc position at the University of Sheffield in the UK where he studied the role of macrophages in tumor progression. Afterwards, Seth was awarded a Marie Curie Intra-European Career Development Fellowship to join Karin de Visser’s lab at the Netherlands Cancer Institute in Amsterdam. During this time, Seth discovered how certain immune cells cooperate with each other to promote metastasis through the suppression of other immune cells. Seth moved to Scotland in the summer of 2016 to focus on the molecular mechanisms that regulate gd T cell function during the evolution of metastasis and cancer progression. Recently, Seth was awarded the British Association for Cancer Research AstraZeneca Young Scientist Frank Rose Award for 2018.
Dr Ryan is a Principal Investigator at the National Cancer Institute. She came to the US in 2007 under a US-Ireland jointly funded program as a Cancer Prevention Fellow. She received all of her formal training in Ireland: from University College Cork (BSc Biochemistry), and University College Dublin (PhD Biochemistry, followed by Masters of Public Health). Dr Ryan is head of the Integrative Molecular Epidemiology Unit (IMEU) of the Laboratory of Human Carcinogenesis, CCR, NCI, and uses an integrative and translational approach to studying population differences in lung cancer, combining epidemiological and laboratory methods to her research. In particular, her research program aims to develop diagnostic and prognostic biomarkers for lung cancer, and uses a precision medicine approach to understand cancer health disparities. She is the author of over 50 research papers and book chapters and has received numerous awards for her work, including the European Association for Cancer Research Young Scientist Award and the AACR Future Leader in Cancer Prevention Award.
Dr Coulter is a Senior Lecturer, working within the Nanomedicine and Biotherapeutics research group at the School of Pharmacy, Queen’s University Belfast. His research has always had a focus on developing strategies to overcome treatment resistance in cancer, with a specific focus on radiotherapy. His work has spanned approaches that include the use of suicide gene therapy and more recently exploiting the unique physical properties of high atomic number nanoparticles as radiosensitisers. Recent iterations have been developed as biologically active formulations, designed to overcome tumour microenvironment properties which are known to confer treatment resistance, in addition to the core particle acting as a radiation dose modifier. This presentation aims to outline some of the successes we have experienced in this space while looking to spark discussion around the key challenges that have limited clinical translation to date.
Title: Reader in Cancer Epidemiology and Prevention, School of Public Health and the Department of Surgery and Cancer, Imperial College London
Dr. Cross is a cancer epidemiologist with a joint appointment in the School of Public Health and in the Department of Surgery and Cancer within the Faculty of Medicine at Imperial College London. She is Head of the Cancer Screening and Prevention Research Group (http://csprg.org.uk). She completed her PhD at Cambridge University and then spent 11 years in the Division of Cancer Epidemiology and Genetics (DCEG) at the National Cancer Institute (NCI), National Institutes of Health (NIH), United States. As a tenure-track investigator at NCI, she was also a mentor for the Yale University– NCI Partnership Training Program and held the position of Assistant Professor Adjunct within the Division of Chronic Disease Epidemiology at Yale University. Her research interests are focused on aetiologic studies of diet and lifestyle factors in relation to cancer risk and survival, as well as colorectal cancer prevention and early detection by screening and surveillance. Her projects include analyses of large international cohort studies as well as the conduct of randomised controlled trials.
Established in 2013, the Burkitt Medal is designed to recognise people with the integrity, compassion and dedication matching that of Denis Burkitt, a Trinity graduate, who is known for his discovery of Burkitt lymphoma. Nominees should demonstrate extraordinary achievement and advancement in the field of cancer internationally.
Denis Parsons Burkitt (28 February 1911 – 23 March 1993), surgeon, was born in Enniskillen, County Fermanagh, Ireland. He was the son of James Parsons Burkitt, a civil engineer. Aged eleven Denis lost his right eye in an accident. He attended Portora Royal School in Enniskillen and Dean Close School, England. In 1929 he applied to Trinity College Dublin to study his father’s profession, engineering, despite a tutor writing to his father expressing doubts if Burkitt would be capable of earning a degree. During his first year at Trinity he joined Room 40, a small group of undergraduates, who met regularly for prayer and Bible study, and committed his life to Jesus Christ. His religious convictions would be a driving force for the rest of his life. Soon after his commitment to Christianity, he felt that God was calling him to devote his life to medicine. He changed his study to medicine and graduated with his MB on 5 July, 1935. After graduating from Trinity College Dublin he continued his surgical training and obtained Fellowship of the Royal College of Surgeons in Edinburgh in 1938. He went on to write his MD entitled ‘Spontaneous rupture of abdominal viscera’ in 1947.
While serving as a ship’s surgeon in 1938, Burkitt decided he would be a surgeon first and a missionary second and hoped to work with the Colonial Service in West Africa. During his five-year sojourn as an army surgeon during World War Two, he married Olive Mary Rogers, a trainee nurse he had met while working as the Resident Surgical Officer at the Prince of Wales Hospital in Plymouth. Denis and Olive had three daughters Judy Howard, Cas and Rachel.
Despite having his application to the Colonial Office being turned down on account of his loss of sight, Burkitt passed a medical and enlisted into the Royal Army Medical Corps. He was posted to a military hospital in Mombasa. Burkitt 'made two major contributions to medical science related to his experience in Africa.
The first was the description, distribution, and ultimately, the etiology of a pediatric cancer that bears his name Burkitt's lymphoma'. Burkitt in 1957 observed a child with swellings in the angles of the jaw. Having an intensely enquiring mind, Burkitt took the details of these cases to the records department, which showed that jaw tumours were common, were often associated with other tumours at unusual sites in children in Uganda. He kept copious notes and 'concluded that these apparently different childhood cancers were all manifestations of a single, hitherto unrecognized tumour complex'. Burkitt published A sarcoma involving the jaws of African children. The newly identified cancer became known as 'Burkitt's lymphoma. He went on to map the geographical distribution of the tumour. Burkitt, together with Dr Dennis Wright, published a book titled 'Burkitt's Lymphoma' in April 1970.
His second major contribution came when, on his return to Britain, Burkitt compared the pattern of diseases in African hospitals with Western diseases. He concluded that many Western diseases which were rare in Africa were the result of diet and lifestyle. He wrote a book Don't Forget Fibre in your Diet, which was an international bestseller.
Although one study showed that people who eat very low levels of fiber—less than 10 grams per day—had an 18 percent higher risk of colorectal cancer, the more general idea that colon cancer is a fiber deficiency disease is now generally considered incorrect by cancer researchers. Nevertheless, research suggests that a diet high in dietary fiber is advised as a precaution against other diseases such as heart disease and diabetes. He had an alternative theory, published in numerous articles and books, that the use of the natural squatting position for defecation protects the natives of Africa and Asia from gastrointestinal diseases.
Burkitt was president of the Christian Medical Fellowship and wrote frequently on religious/medical themes. He received the Bower Award and Prize in 1992. He died on 23 March 1993 in Gloucester and was buried in Bisley, Gloucestershire, England.
Deadline for submissions – 1 March 2019
Completed forms to be returned to Professor John Reynolds, Chair of the Selection Committee, by e-mail: CONFSM@tcd.ie
Burkitt Medal Awardee 2017 – Mariano Barbacid, PhD/strong>
Mariano Barbacid is AXA-CNIO Professor of Molecular Oncology at the Spanish National Cancer Research Centre in Madrid. Born in Madrid, Mariano Barbacid was awarded his PhD from the Universidad Complutense in 1974. Having trained as a postdoctoral fellow at the National Cancer Institute (NCI), Bethesda, Maryland, USA, in 1978 he started his own group to work on the molecular biology of human tumours. Dr Barbacid’s work led to the isolation of the first human cancer gene, H-RAS, in the spring of 1982 and to the identification of the first mutation associated with the development of human cancer. These findings, also made independently by two other groups, have been seminal to establish the molecular basis of human cancer. Dr Barbacid’s achievements have been recognised widely. In 2012, he was inducted to the National Academy of Sciences of the US as a Foreign Member and in 2014, elected Fellow of the AACR Academy. He holds three Honorary degrees, and apart from being acknowledged for his achievements in Spain, Dr Barbacid received several international awards including the Steiner Prize (Bern, 1988), Ipsen Prize (Paris, 1994), Brupbaher Cancer Research Prize (Zurich, 2005), the Medal of Honour of the International Agency for Cancer Research (Lyon, 2007) and an Endowed Chair from the AXA Research Fund (Paris, 2011). He has received two Advanced Grants from the European Research Council since their inception in 2008. To date, Dr Barbacid has authored a total of 300 publications, including 221 original research articles in journals with impact factor, 32 invited reviews in refereed journals and 47 book chapters.
Burkitt Medal Awardee 2016 – Paul Brennan, PhD
Paul Brennan is the Head of the Genetics Section of the International Agency for Research on Cancer (IARC), Lyon, France. IARC is the specialised cancer agency of the World Health Organization (WHO) with the objective to promote international collaboration in cancer research. Dr Brennan's primary area of work is conducting very large multi-partner studies that aim to use genetics to understand the causes of cancer. This is done by exploring the genome of individuals who develop cancer, in order to identify clues as to why they are more susceptible. It also involves investigating the genomes of the tumours, in order to identify what triggered the tumour in the first place. His group works with colleagues in many different parts of the world, with active studies underway in central and eastern Europe, central and south-east Asia, and Latin America. Among others, Dr Brennan has collaborators in Trinity College Dublin. Dr Brennan and his colleagues at IARC have made an outstanding contribution to promoting international collaboration in the study of cancer for the ultimate benefit of those affected by the disease.
Burkitt Medal Awardee 2015 – Riccardo Dalla-Favera, MD, MSc
Riccardo Dalla-Favera is Professor of Pathology & Cell Biology and Director, Institute for Cancer Genetics at Columbia University, New York, USA. Professor Dalla-Favera’s career started with his pioneering work on the cloning and chromosomal mapping of human proto-oncogenes, including c-MYC. This work established the basis for the seminal work on the involvement of c-MYC in chromosomal translocations in Burkitt’s lymphoma. His research has continued to yield new insights into the pathogenesis of human B cell lymphomas, and, in particular, on the identification of the genetic lesions and biological mechanisms responsible for the development of these diseases.
Burkitt Medal Awardee 2014 – John L. Ziegler, MD, MSc
John Ziegler, Founding Director, Global Health Sciences Graduate Program University of California San Francisco (UCSF), USA, received his undergraduate degree (BA, English Literature) from Amherst College, Amherst Massachusetts, and his MD from Cornell University Medical School in New York City. Following medical house staff training at Bellevue Hospital in New York, he joined the National Cancer Institute (NCI) in 1966, beginning a life-long career in cancer research and care. In 1967 he was assigned to begin a long collaboration with Makerere University in Kampala, Uganda, studying Burkitt’s lymphoma and other indigenous cancers. Together with Ugandan counterparts, he developed curative therapies for lymphoma and established a cancer institute that today has expanded to a major center of excellence in sub Saharan Africa. After five years Ziegler returned to NCI to head clinical oncology, and in 1981 moved to UCSF. The AIDS pandemic made its first appearance in San Francisco, heralded by opportunistic infections and two malignancies – Kaposi’s sarcoma and non Hodgkin’s lymphoma. Ziegler and colleagues made important contributions to this field both in California and back in Uganda. In his later career, earning an MSc in epidemiology from the London School of Hygiene and Tropical Medicine, Ziegler headed a cancer genetics clinic at UCSF, and most recently was founding director of a global health Master’s degree.
Burkitt Medal Awardee 2013 – Murray F. Brennan, MD
Born in Auckland, New Zealand, Dr. Murray Brennan received a degree in mathematics from the University of New Zealand and a medical degree from the University of Otago in 1964. In 1970 he worked at Peter Bent Brigham Hospital, Harvard Medical School, and at the Joslin Research Laboratories. After residency at the Brigham, Dr. Brennan joined the National Cancer Institute. In 1981, he joined Memorial Sloan-Kettering Cancer Center (MSKCC) as Chief of Gastric and Mixed Tumor Service. Dr. Brennan was Chairman of the Department of Surgery at MSKCC from 1985 until June of 2006. He currently holds the Benno C. Schmidt Chair in Clinical Oncology and is Director of the International Center and Vice President for International Programs at MSKCC. He has lectured throughout the world and authored and co-authored more than 1,000 scientific papers and book chapters focusing on surgical oncology, endocrinology, metabolism, and nutrition, and is the author of a book on soft tissue sarcoma. Dr Brennan received numerous honours for his contribution to oncology. Dr. Brennan’s interest, in addition to patient care and research, has been the development of young surgeons.
Online Registration https://ti.to/tcdAlumni/11th-tcd-international-cancer-conference-2019
The registration fee includes morning coffee, lunch, afternoon tea, reception on both days of the conference.
Burkitt award dinner in Trinity College Dining Hall is €50 (additional to the registration fee).
To submit abstracts visit https://bytesizedhost.co.uk/tcdc/
The deadline for abstract submission is Friday July 19th 2019
Abstract submission guidelines - 300 words max (excluding title and affiliations) structured under the following headings: Introduction, Methods, Results, Discussion. No tables or figures should be inserted to the abstract title or text.
Should you have any queries throughout the abstract submission process, please contact Professor Jacintha O'Sullivan
If you are interested in sponsoring the 2019 International Cancer Conference, please contact:
Tel: 00353 1 896 3376